Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART
F Pandolfi, M Pierdominici, M Marziali, ML Bernardi… - Clinical …, 2000 - Elsevier
During HIV disease an increased in vitro apoptosis of peripheral blood mononuclear cells
has been demonstrated. This can be reversed in vitro by interleukin (IL)-2. Recent trials with
highly active antiretroviral therapy (HAART) and IL-2 in HIV-1-infected patients showed
promising immunological and clinical results. Here we investigated the effects of
subcutaneous low-dose IL-2 administration in combination with HAART on in vitro apoptosis
and the relationship between apoptosis, CD4+ counts, and HIV replication. Twenty-two …
has been demonstrated. This can be reversed in vitro by interleukin (IL)-2. Recent trials with
highly active antiretroviral therapy (HAART) and IL-2 in HIV-1-infected patients showed
promising immunological and clinical results. Here we investigated the effects of
subcutaneous low-dose IL-2 administration in combination with HAART on in vitro apoptosis
and the relationship between apoptosis, CD4+ counts, and HIV replication. Twenty-two …