Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
SH Lecker - Current Opinion in Clinical Nutrition & Metabolic Care, 2003 - journals.lww.com
SH Lecker
Current Opinion in Clinical Nutrition & Metabolic Care, 2003•journals.lww.comIt seems likely that multiple pathways of ubiquitin conjugation are activated in parallel in
atrophying muscle, perhaps to target for degradation specific classes of muscle proteins.
The emerging challenge will be to define the protein targets for, as well as inhibitors of,
these E3s.
atrophying muscle, perhaps to target for degradation specific classes of muscle proteins.
The emerging challenge will be to define the protein targets for, as well as inhibitors of,
these E3s.
Abstract
It seems likely that multiple pathways of ubiquitin conjugation are activated in parallel in atrophying muscle, perhaps to target for degradation specific classes of muscle proteins. The emerging challenge will be to define the protein targets for, as well as inhibitors of, these E3s.
Lippincott Williams & Wilkins