The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.
T Fujita, GP Nolan, HC Liou, ML Scott… - Genes & …, 1993 - genesdev.cshlp.org
T Fujita, GP Nolan, HC Liou, ML Scott, D Baltimore
Genes & development, 1993•genesdev.cshlp.orgThe candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I
kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we
show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product
superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in
vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence
of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a …
kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we
show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product
superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in
vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence
of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a …
Abstract
The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.
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