Human CD4+ CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production
I Bellinghausen, B Klostermann, J Knop… - Journal of allergy and …, 2003 - Elsevier
Background: Recently, it has been established that CD4+ CD25+ T cells with regulatory
capacity are present in human peripheral blood, inhibiting allogeneic proliferation and
cytokine production of preactivated CD4+ CD25− respond-er T cells. Objective: The aim of
this study was to analyze in an allergen-specific setting whether such regulatory CD4+
CD25+ T cells also exist and function normally in atopic individuals, especially concerning
the inhibition of TH2 cytokines. Methods: For this purpose, CD4+ CD25− or CD4+ CD25+ T …
capacity are present in human peripheral blood, inhibiting allogeneic proliferation and
cytokine production of preactivated CD4+ CD25− respond-er T cells. Objective: The aim of
this study was to analyze in an allergen-specific setting whether such regulatory CD4+
CD25+ T cells also exist and function normally in atopic individuals, especially concerning
the inhibition of TH2 cytokines. Methods: For this purpose, CD4+ CD25− or CD4+ CD25+ T …