Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells
C McMenamin, C Pimm, M McKersey, PG Holt - Science, 1994 - science.org
C McMenamin, C Pimm, M McKersey, PG Holt
Science, 1994•science.orgIndirect evidence implicates γδ T cells in the cross-regulation of CD4 αβ T cell responses.
Adoptive transfer of small numbers of γδ T cells from ovalbumin (OVA)-tolerant mice
selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without
affecting parallel IgG responses. Challenge of these γδ T cells in vitro with specific antigen
resulted in production of high levels of interferon γ. The effects of the γδ T cells may be
mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for …
Adoptive transfer of small numbers of γδ T cells from ovalbumin (OVA)-tolerant mice
selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without
affecting parallel IgG responses. Challenge of these γδ T cells in vitro with specific antigen
resulted in production of high levels of interferon γ. The effects of the γδ T cells may be
mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for …
Indirect evidence implicates γδ T cells in the cross-regulation of CD4 αβ T cell responses. Adoptive transfer of small numbers of γδ T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2 -dependent immunoglobulin E(IgE) antibody production without affecting parallel IgG responses. Challenge of these γδ T cells in vitro with specific antigen resulted in production of high levels of interferon γ. The effects of the γδ T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for specific CD4 TH2 cells.
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