Hypoxia, a strong inducer for vascular endothelial growth factor (VEGF)/vascular permeable
factor (VPF) expression, regulates leukocyte infiltration through the up-regulation of
adhesion molecules and chemokine release. To determine whether VEGF/VPF is directly
involved in chemokine secretion, we analyzed its effects on chemokine expression in human
brain microvascular endothelial cells (HBMECs) by using a human cytokine cDNA array kit.
Cytokine array analysis revealed a significant increase in expression of monocyte …