Developmental patterns of NF-κB activation during acute hypoxia in the caudal brainstem of the rat
N Simakajornboon, E Gozal, D Gozal - Developmental Brain Research, 2001 - Elsevier
NF-κB, an ubiquitous transcription factor which plays a major role in the regulation of stress-
related genes, is activated during environmental hypoxia in the dorsocaudal brainstem of
adult rats. To examine the developmental pattern of NF-κB basal activity in the brainstem
and the response to hypoxia, electromobility shift assays and immunohistochemical staining
for the P65 subunit of NF-κB were performed in caudal brainstem samples of rats at 2, 5, 10,
15, and 60 days postnatal age, following normoxic or hypoxic (1 h in 10% O2) exposures. In …
related genes, is activated during environmental hypoxia in the dorsocaudal brainstem of
adult rats. To examine the developmental pattern of NF-κB basal activity in the brainstem
and the response to hypoxia, electromobility shift assays and immunohistochemical staining
for the P65 subunit of NF-κB were performed in caudal brainstem samples of rats at 2, 5, 10,
15, and 60 days postnatal age, following normoxic or hypoxic (1 h in 10% O2) exposures. In …