[HTML][HTML] Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα Gene (∗)
Y Hashimoto, J Ware - Journal of Biological Chemistry, 1995 - ASBMB
Platelet glycoprotein (GP) Ib-IX-V is a multisubunit adhesion receptor that supports platelet
attachment to thrombogenic surfaces at sites of vascular injury. The congenital absence of
the receptor results in a bleeding disorder associated with" giant" platelets, a condition
linking the expression of the complex to platelet morphogenesis. To understand better the
expression of the GP Ib-IX-V complex, studies were undertaken to define the essential
genetic elements supporting the expression of the α-subunit of the complex (GP Ibα). GP Ibα …
attachment to thrombogenic surfaces at sites of vascular injury. The congenital absence of
the receptor results in a bleeding disorder associated with" giant" platelets, a condition
linking the expression of the complex to platelet morphogenesis. To understand better the
expression of the GP Ib-IX-V complex, studies were undertaken to define the essential
genetic elements supporting the expression of the α-subunit of the complex (GP Ibα). GP Ibα …