[HTML][HTML] Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
SC Bunnell, M Diehn, MB Yaffe, PR Findell… - Journal of Biological …, 2000 - ASBMB
Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3′-kinase
to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-
regulated kinase activity. Here we demonstrate interactions between Itk and crucial
components of TCR-dependent signaling pathways. First, the inositide-binding pocket of the
Itk pleckstrin homology domain directs the constitutive association of Itk with buoyant
membranes that are the primary site of TCR activation and are enriched in both Lck and …
to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-
regulated kinase activity. Here we demonstrate interactions between Itk and crucial
components of TCR-dependent signaling pathways. First, the inositide-binding pocket of the
Itk pleckstrin homology domain directs the constitutive association of Itk with buoyant
membranes that are the primary site of TCR activation and are enriched in both Lck and …
