Induction of CTL response by a minimal epitope vaccine in HLA A∗ 0201/DR1 transgenic mice: dependence on HLA class II restricted TH response
L BenMohamed, R Krishnan, J Longmate, C Auge… - Human Immunology, 2000 - Elsevier
CTL play a pivotal role in the immune response during viral infections. In this study, the HLA
class II restricted TH requirement for optimal in vivo induction of HLA class I restricted CTL
responses has been investigated. Towards this goal, transgenic mice expressing both HLA
class I (A∗ 0201 or A2. 1) and class II (DRB1∗ 0101 or DR1) molecules have been derived.
Immunization of these mice with an HLA A∗ 0201-restricted and CMV-specific CTL epitope
(pp65495–503), and either of three different tetanus toxin-derived MHC class II-binding TH …
class II restricted TH requirement for optimal in vivo induction of HLA class I restricted CTL
responses has been investigated. Towards this goal, transgenic mice expressing both HLA
class I (A∗ 0201 or A2. 1) and class II (DRB1∗ 0101 or DR1) molecules have been derived.
Immunization of these mice with an HLA A∗ 0201-restricted and CMV-specific CTL epitope
(pp65495–503), and either of three different tetanus toxin-derived MHC class II-binding TH …