[HTML][HTML] Identification of an 8-lipoxygenase pathway in nervous tissue of Aplysia californica
DJ Steel, TL Tieman, JH Schwartz… - Journal of Biological …, 1997 - ASBMB
Arachidonic acid is converted to (8R)-hydroperoxyeicosa-5, 9, 11, 14-tetraenoic acid (8-
HPETE) during incubations with homogenates of the central nervous system of the marine
mollusc, Aplysia californica. 8-HPETE can be reduced to the corresponding hydroxy acid or
be enzymatically converted to a newly identified metabolite, 8-ketoeicosa-5, 9, 11, 14-
tetraenoic acid (8-KETE). These metabolites were identified by high performance liquid
chromatography, UV absorbance, and gas chromatography/mass spectrometry …
HPETE) during incubations with homogenates of the central nervous system of the marine
mollusc, Aplysia californica. 8-HPETE can be reduced to the corresponding hydroxy acid or
be enzymatically converted to a newly identified metabolite, 8-ketoeicosa-5, 9, 11, 14-
tetraenoic acid (8-KETE). These metabolites were identified by high performance liquid
chromatography, UV absorbance, and gas chromatography/mass spectrometry …