[HTML][HTML] Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes
YYC Lo, TF Cruz - Journal of Biological Chemistry, 1995 - ASBMB
The cytokine tumor necrosis factor α (TNFα) and the growth factor basic fibroblast growth
factor (bFGF) are known to induce early response genes such as c-fos and c-jun in various
cell types. Activation of AP-1, a heterodimeric complex of Fos and Jun proteins, is required
for matrix metalloproteinase production and cell proliferation. However, the signaling
pathways by which these two factors influence the expression and activities of AP-1 remain
currently poorly characterized. Several studies have shown that cytokines induce reactive …
factor (bFGF) are known to induce early response genes such as c-fos and c-jun in various
cell types. Activation of AP-1, a heterodimeric complex of Fos and Jun proteins, is required
for matrix metalloproteinase production and cell proliferation. However, the signaling
pathways by which these two factors influence the expression and activities of AP-1 remain
currently poorly characterized. Several studies have shown that cytokines induce reactive …