Endogenous salivary inhibitors of human immunodeficiency virus
DC Shugars, AL Alexander, K Fu, SA Freel - Archives of oral biology, 1999 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) is rarely transmitted through salivary
secretions, due in part to the presence of endogenous inhibitors. Here, the protective
characteristics of the intraoral environment are summarized and inhibitory factors that
reduce HIV-1 infectivity in vitro described, focusing on secretory leucocyte protease inhibitor
(SLPI), a 12-kDa mucosal protein that blocks HIV infection in several cell-culture systems.
SLPI appears to interact with a cellular surface molecule to limit viral entry into target cells …
secretions, due in part to the presence of endogenous inhibitors. Here, the protective
characteristics of the intraoral environment are summarized and inhibitory factors that
reduce HIV-1 infectivity in vitro described, focusing on secretory leucocyte protease inhibitor
(SLPI), a 12-kDa mucosal protein that blocks HIV infection in several cell-culture systems.
SLPI appears to interact with a cellular surface molecule to limit viral entry into target cells …