Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions
KC O'Connor, T Chitnis, DE Griffin, S Piyasirisilp… - Journal of …, 2003 - Elsevier
The presence of autoantibodies to the immunodominant antigen, myelin basic protein
(MBP), in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS)
has been poorly characterized. Many studies report detectable levels of autoantibodies to
myelin basic protein though other studies, using similar techniques, report their absence. We
compared a solution-phase assay that has detected clinically relevant autoantibodies in
diabetes and other autoimmune diseases to solid phase assays similar to those used in …
(MBP), in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS)
has been poorly characterized. Many studies report detectable levels of autoantibodies to
myelin basic protein though other studies, using similar techniques, report their absence. We
compared a solution-phase assay that has detected clinically relevant autoantibodies in
diabetes and other autoimmune diseases to solid phase assays similar to those used in …