Multiple sclerosis—from probable to definite diagnosis: a 7-year prospective study

A Achiron, Y Barak - Archives of neurology, 2000 - jamanetwork.com
Objectives To investigate the rate of progression from probable to clinically definite multiple
sclerosis (MS) and to define patients who had rapidly (within 1 year) progressed to a definite
diagnosis. Design A 7-year prospective study. Patients A group of 163 patients experiencing
their first episode of neurologic symptoms suggestive of MS. All patients had brain magnetic
resonance imaging that demonstrated at least 3 demyelinating lesions at onset. Results
Within the follow-up period (mean, 42 months; range, 13-84 months), 136 patients (83.4%) …