In vitro studies of the role of monocytes in the immunosuppression associated with natural measles virus infections
DE Griffin, RT Johnson, VG Tamashiro… - Clinical immunology and …, 1987 - Elsevier
Measles is associated with suppression of mitogen-induced proliferative responses. The
role of monocytes in depressed responses to phytohemagglutinin during measles was
assessed. Depleting peripheral blood mononuclear cells of adherent cells decreased,
increased, and did not change proliferative responses in essentially equal numbers of
individuals. Inhibition of prostaglandin synthesis by indomethacin significantly increased
proliferation (P= 0.009) but often not to normal values. Addition of supplemental interleukin 1 …
role of monocytes in depressed responses to phytohemagglutinin during measles was
assessed. Depleting peripheral blood mononuclear cells of adherent cells decreased,
increased, and did not change proliferative responses in essentially equal numbers of
individuals. Inhibition of prostaglandin synthesis by indomethacin significantly increased
proliferation (P= 0.009) but often not to normal values. Addition of supplemental interleukin 1 …