[HTML][HTML] Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
Parathyroid hormone (PTH) and its related peptide regulate endochondral ossification by
inhibiting chondrocyte differentiation toward hypertrophy. However, the intracellular pathway
for transducing PTH/PTH-related peptide signals in chondrocytes remains unclear. Here, we
show that this pathway is mediated by mitogen-activated protein kinase (MAPK) p38.
Incubation of hypertrophic chondrocytes with PTH (1–34) induces an inhibition of p38 kinase
activity in a time-and dose-dependent manner. Inhibition of protein kinase C prevents PTH …
inhibiting chondrocyte differentiation toward hypertrophy. However, the intracellular pathway
for transducing PTH/PTH-related peptide signals in chondrocytes remains unclear. Here, we
show that this pathway is mediated by mitogen-activated protein kinase (MAPK) p38.
Incubation of hypertrophic chondrocytes with PTH (1–34) induces an inhibition of p38 kinase
activity in a time-and dose-dependent manner. Inhibition of protein kinase C prevents PTH …