Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms
TR Golub, GF Barker, K Stegmaier… - Molecular Aspects of …, 1996 - Springer
TR Golub, GF Barker, K Stegmaier, DG Gilliland
Molecular Aspects of Myeloid Stem Cell Development, 1996•SpringerCloning of chromosome translocation breakpoints have identified abnormal gene products
which contribute to the pathogenesis of hematologic malignancy. Examples include the PML-
RARα fusion associated with t (15; 17) acute promyelocytic leukemia (APML)(1'3), the AMLl-
ETO fusion associated with t (8; 21) acute myeloid leukemia (4), the CBFβ-MYHII fusion
associated with inv (16) acute myelomonocytic leukemia and eosinophilia (5), and MLL
fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid …
which contribute to the pathogenesis of hematologic malignancy. Examples include the PML-
RARα fusion associated with t (15; 17) acute promyelocytic leukemia (APML)(1'3), the AMLl-
ETO fusion associated with t (8; 21) acute myeloid leukemia (4), the CBFβ-MYHII fusion
associated with inv (16) acute myelomonocytic leukemia and eosinophilia (5), and MLL
fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid …
Abstract
Cloning of chromosome translocation breakpoints have identified abnormal gene products which contribute to the pathogenesis of hematologic malignancy. Examples include the PML-RARα fusion associated with t(15; 17) acute promyelocytic leukemia (APML)(1’3), the AMLl-ETO fusion associated with t(8;21) acute myeloid leukemia (4), the CBFβ-MYHII fusion associated with inv(16) acute myelomonocytic leukemia and eosinophilia (5), and MLL fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid leukemias (6).
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