The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of human African trypanosomiasis
PGE Kennedy - Journal of Neuroimmunology, 1999 - Elsevier
Drug treatment of late-stage human African Trypanosomiasis (HAT) in which the central
nervous system (CNS) is involved may be complicated by a severe post-treatment reactive
encephalopathy (PTRE) which can be fatal in up to 10% of cases. In order to understand the
immunopathogenesis of this complication, an experimental mouse model has been
developed that mirrors many of the pathological features of the PTRE in humans, and which
allows various anti-inflammatory therapeutic regimes to be evaluated. Following the …
nervous system (CNS) is involved may be complicated by a severe post-treatment reactive
encephalopathy (PTRE) which can be fatal in up to 10% of cases. In order to understand the
immunopathogenesis of this complication, an experimental mouse model has been
developed that mirrors many of the pathological features of the PTRE in humans, and which
allows various anti-inflammatory therapeutic regimes to be evaluated. Following the …