Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness
J Pepin, C Guern, L Ethier, F Milord, B Mpia… - The Lancet, 1989 - Elsevier
J Pepin, C Guern, L Ethier, F Milord, B Mpia, D Mansinsa
The Lancet, 1989•ElsevierIn a prospective randomised trial, 620 patients who had Trypanosoma brucei gambiense
trypanosomiasis with central nervous system involvement were treated either with
prednisolone plus melarsoprol or with melarsoprol only. 598 patients were evaluable:
morbidity and death associated with melarsoprol-induced encephalopathy was reduced in
patients who were given prednisolone. The two groups did not differ either in the incidence
of other complications of melarsoprol therapy or in relapse rate after melarsoprol therapy …
trypanosomiasis with central nervous system involvement were treated either with
prednisolone plus melarsoprol or with melarsoprol only. 598 patients were evaluable:
morbidity and death associated with melarsoprol-induced encephalopathy was reduced in
patients who were given prednisolone. The two groups did not differ either in the incidence
of other complications of melarsoprol therapy or in relapse rate after melarsoprol therapy …
Abstract
In a prospective randomised trial, 620 patients who had Trypanosoma brucei gambiense trypanosomiasis with central nervous system involvement were treated either with prednisolone plus melarsoprol or with melarsoprol only. 598 patients were evaluable: morbidity and death associated with melarsoprol-induced encephalopathy was reduced in patients who were given prednisolone. The two groups did not differ either in the incidence of other complications of melarsoprol therapy or in relapse rate after melarsoprol therapy. The cost of prednisolone would be outweighed by savings on the treatment of encephalopathies in such patients.
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