Cloning of the NCX2 isoform of the plasma membrane Na (+)-Ca2+ exchanger

Z Li, S Matsuoka, LV Hryshko, DA Nicoll… - Journal of Biological …, 1994 - ASBMB
The Na (+)-Ca2+ exchanger is an important regulator of cellular Ca2+ levels, and one
isoform of this transporter, NCX1, has been cloned previously (Nicoll, DA, Longoni, S., and
Philipson, KD (1990) Science 250, 562-565). We now report the cloning of a second isoform
(NCX2) of the Na (+)-Ca2+ exchanger which was present in a rat brain cDNA library. NCX2
is predicted to code for a protein of 921 amino acids. NCX1 and NCX2 are 61 and 65%
identical at the nucleotide and amino acid levels, respectively, and are the products of …