[HTML][HTML] Pneumonitis and emphysema in sp-C gene targeted mice

SW Glasser, EA Detmer, M Ikegami, CL Na… - Journal of Biological …, 2003 - ASBMB
SP-C-deficient (SP-C−/−) mice developed a severe pulmonary disorder associated with
emphysema, monocytic infiltrates, epithelial cell dysplasia, and atypical accumulations of
intracellular lipids in type II epithelial cells and alveolar macrophages. Whereas alveolar and
tissue surfactant phospholipid pools were increased, levels of other surfactant proteins were
not altered (SP-B) or were modestly increased (SP-A and SP-D). Analysis of pressure-
volume curves and forced oscillatory dynamics demonstrated abnormal respiratory …