Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis
I Kotani, A Sato, H Hayakawa, T Urano, Y Takada… - Thrombosis research, 1995 - Elsevier
To elucidate the pathophysiology of idiopathic pulmonary fibrosis (IPF), we examined
procoagulant (tissue factor: TF), fibrinolytic (tissue type plasminogen activator: t-PA and
urokinase type plasminogen activator: u-PA) and antifibrinolytic (plasminogen activator
inhibitor-1: PAI-1 and PAI-2) activities in bronchoalveolar lavage (BAL) supernatant fluids
and BAL cell lysates obtained from IPF patients. The results indicated that TF levels in BAL
supernatant fluids from IPF patients were higher than those of normal subjects, especially in …
procoagulant (tissue factor: TF), fibrinolytic (tissue type plasminogen activator: t-PA and
urokinase type plasminogen activator: u-PA) and antifibrinolytic (plasminogen activator
inhibitor-1: PAI-1 and PAI-2) activities in bronchoalveolar lavage (BAL) supernatant fluids
and BAL cell lysates obtained from IPF patients. The results indicated that TF levels in BAL
supernatant fluids from IPF patients were higher than those of normal subjects, especially in …