[HTML][HTML] Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD (P) H …
S Dhakshinamoorthy, AK Jaiswal - Journal of Biological Chemistry, 2000 - ASBMB
The antioxidant response element (ARE) is known to regulate expression and induction of
NQO1, GST Ya, and other detoxifying enzyme genes in response to antioxidants and
xenobiotics. The nuclear transcription factor Nrf2 and Nrf1 bind to the ARE and positively
regulate expression and induction of the NQO1 and GST Ya genes. In this study, we
demonstrate that overexpression of small Maf (MafG and MafK) proteins negatively regulate
ARE-mediated expression and tert-butyl hydroquinone induction of the NQO1 and GST Ya …
NQO1, GST Ya, and other detoxifying enzyme genes in response to antioxidants and
xenobiotics. The nuclear transcription factor Nrf2 and Nrf1 bind to the ARE and positively
regulate expression and induction of the NQO1 and GST Ya genes. In this study, we
demonstrate that overexpression of small Maf (MafG and MafK) proteins negatively regulate
ARE-mediated expression and tert-butyl hydroquinone induction of the NQO1 and GST Ya …