Ubiquitin gene expression is increased in human muscle undergoing neurogenic involvement
M Llovera, C García-Martínez, N Agell… - Neurochemistry …, 1999 - Elsevier
Histological features of neurogenic muscle involvement included type grouping, muscle fiber
atrophy, and target fibers. In muscles with myofiber atrophy and target fibers, we found an
increased expression of the genes encoding for the ubiquitin-ATP-dependent proteolytic
system. Thus, in patients with target fibers, a 5.2-and a 3.9-fold increase were observed for
the 2.4 and 1.2 kb transcripts, respectively, while in those with atrophic angulated
hyperoxidative fibers, a 3.9-and a 4.4-fold increase were observed for the 2.4 and 1.2 kb …
atrophy, and target fibers. In muscles with myofiber atrophy and target fibers, we found an
increased expression of the genes encoding for the ubiquitin-ATP-dependent proteolytic
system. Thus, in patients with target fibers, a 5.2-and a 3.9-fold increase were observed for
the 2.4 and 1.2 kb transcripts, respectively, while in those with atrophic angulated
hyperoxidative fibers, a 3.9-and a 4.4-fold increase were observed for the 2.4 and 1.2 kb …