Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA
T Mutis, K Ghoreschi, E Schrama, J Kamp… - Biology of Blood and …, 2002 - astctjournal.org
Cytotoxic T-cells (CTLs) specific for the hematopoietic system-restricted minor
histocompatibility antigen (mHag) HA-1 efficiently lyse HA-1-positive leukemic cells without
affecting nonhematopoietic cells. HA-1-specific CTLs are thus potential tools for adoptive
immunotherapy of relapsed leukemia after HLA-matched-HA-1-mismatched stem cell
transplantation (SCT). In vitro generation of HA-1-specific CTLs from SC donors is possible
using dendritic cells (DCs) pulsed with synthetic HA-1 peptide as stimulator cells. However …
histocompatibility antigen (mHag) HA-1 efficiently lyse HA-1-positive leukemic cells without
affecting nonhematopoietic cells. HA-1-specific CTLs are thus potential tools for adoptive
immunotherapy of relapsed leukemia after HLA-matched-HA-1-mismatched stem cell
transplantation (SCT). In vitro generation of HA-1-specific CTLs from SC donors is possible
using dendritic cells (DCs) pulsed with synthetic HA-1 peptide as stimulator cells. However …