Monoclonal antibody analysis of skin in chronic murine graft vs host disease produced across minor histocompatibility barriers
R Giorno, KL Choi, HR Katz, HN Claman - Cellular immunology, 1987 - Elsevier
Chronic graft vs host disease (GVHD) across minor histocompatibility barriers was produced
in BALB/c mice by the injection of spleen cells from B10. D2 mice. Changes in the skin were
analyzed in frozen sections using a panel of monoclonal antibodies detected by
immunoperoxidase methods. Compared to control animals, a number of changes occurred
in the skin of animals with chronic GVHD. In the epidermis, there were increased numbers of
Thy-1-positive dendritic cells; keratinocytes expressed Thy-1 and Ia antigens. T lymphocytes …
in BALB/c mice by the injection of spleen cells from B10. D2 mice. Changes in the skin were
analyzed in frozen sections using a panel of monoclonal antibodies detected by
immunoperoxidase methods. Compared to control animals, a number of changes occurred
in the skin of animals with chronic GVHD. In the epidermis, there were increased numbers of
Thy-1-positive dendritic cells; keratinocytes expressed Thy-1 and Ia antigens. T lymphocytes …