Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with …
TM Friedman, D Statton, SC Jones… - Biology of Blood and …, 2001 - astctjournal.org
Lethal graft-versus-host disease (GVHD) can be induced after hematopoietic stem cell
transplantation between major histocompatibility complex-matched murine strains
expressing multiple minor histocompatibility antigen (miHA) differences. In the C57BL/6By
(B6)--> C. B10-H2b/LiMcdJ (BALB. B) irradiation model, both CD4+ and CD8+ donor T cells
can mediate lethal GVHD, whereas in the B6--> CXB-2/By (CXBE) model, in which the
recipient expresses a subset of BALB. B miHA, only the CD8+ T cells are lethal. Phenotypic …
transplantation between major histocompatibility complex-matched murine strains
expressing multiple minor histocompatibility antigen (miHA) differences. In the C57BL/6By
(B6)--> C. B10-H2b/LiMcdJ (BALB. B) irradiation model, both CD4+ and CD8+ donor T cells
can mediate lethal GVHD, whereas in the B6--> CXB-2/By (CXBE) model, in which the
recipient expresses a subset of BALB. B miHA, only the CD8+ T cells are lethal. Phenotypic …