Why do we reject a graft? Role of indirect allorecognition in graft rejection

MH Sayegh - Kidney international, 1999 - kidney-international.org
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital and
Harvard Medical School, Boston, Massachusetts, USA renal transplant dysfunction, as
manifested by a slow, progressive rise in serum creatinine, developed; the decreasing renal
function was associated with proteinuria (1 to 2 g/24 hr). The erratic cyclosporine levels and
blood pressure readings led to the suspicion that he remained noncompliant with his
medications. A renal transplant biopsy one year ago (when his serum creatinine was 4.0 …