Endothelial and leukocyte adhesion molecules in inflammation and disease.
R Winn, N Vedder, C Ramamoorthy… - Blood Coagulation & …, 1998 - europepmc.org
Blood Coagulation & Fibrinolysis: an International Journal in …, 1998•europepmc.org
Injury associated with ischemia and reperfusion is a significant factor in a number of clinical
diseases. We have completed a number of preclinical studies investigating the blockade of
leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of
other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were
effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury
following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion …
diseases. We have completed a number of preclinical studies investigating the blockade of
leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of
other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were
effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury
following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion …
Injury associated with ischemia and reperfusion is a significant factor in a number of clinical diseases. We have completed a number of preclinical studies investigating the blockade of leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion injury was also reduced by synthetic oligosaccharide sLe (x). These studies suggest that adhesion blockade might be effective in the clinical setting.
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