Familial prolactinoma

M Berezin, A Karasik - Clinical Endocrinology, 1995 - Wiley Online Library
M Berezin, A Karasik
Clinical Endocrinology, 1995Wiley Online Library
BACKGROUND Apart from the rare association with type I multiple endocrine neoplasia
(MEN‐1), familial types of prolactinoma have not been reported. PATIENTS AND
MEASUREMENTS Eight hyperprolacti‐naemic patients in four families and 18 of their first
and second‐degree relatives (parents, children and grandchildren) were examined.
Hormone levels were measured, as well as other biochemical parameters. RESULTS
Prolactinoma was diagnosed In more than one member of each of the four families …
Summary
BACKGROUND Apart from the rare association with type I multiple endocrine neoplasia (MEN‐1), familial types of prolactinoma have not been reported.
PATIENTS AND MEASUREMENTS Eight hyperprolacti‐naemic patients in four families and 18 of their first and second‐degree relatives (parents, children and grandchildren) were examined. Hormone levels were measured, as well as other biochemical parameters.
RESULTS Prolactinoma was diagnosed In more than one member of each of the four families.
CONCLUSION Familial prolactinoma Is a distinct entity which Is probably due to a genetic mutation promoting lactotroph proliferation.
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