Molecular basis of the little mouse phenotype and implications for cell type-specific growth
SC Lin, CR Lin, I Gukovsky, AJ Lusis, PE Sawchenko… - Nature, 1993 - nature.com
SC Lin, CR Lin, I Gukovsky, AJ Lusis, PE Sawchenko, MG Rosenfeld
Nature, 1993•nature.comThe molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic
anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the
growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary
reveals spatially distinct proliferative zones of growth hormone-producing stem cells and
mature somatotrophs, each regulated by a different trophic factor. This sequential growth
factor requirement for a specific cell type may exemplify a common strategy for regulating …
anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the
growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary
reveals spatially distinct proliferative zones of growth hormone-producing stem cells and
mature somatotrophs, each regulated by a different trophic factor. This sequential growth
factor requirement for a specific cell type may exemplify a common strategy for regulating …
Abstract
The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.
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