[HTML][HTML] Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function

L Pei - Journal of Biological Chemistry, 2000 - ASBMB
Pituitary tumor-transforming gene (PTTG) is a recently characterized oncogene that can act
as a transcriptional activator. In this study, we have characterized the transactivation domain
of PTTG. Transient transfection of fusion constructs containing GAL4 DNA-binding domain
and different parts of PTTG indicated the transactivation domain of PTTG is located between
amino acids 119 and 164. Mitogen-activated protein (MAP) kinase cascade is important in
the regulation of cell growth, apoptosis, and differentiation. Therefore, we have explored the …