Detection of chromosomal imbalances in growth hormone-secreting pituitary tumors by comparative genomic hybridization
ABY Hui, JCS Pang, CW Ko, HK Ng - Human pathology, 1999 - Elsevier
Although recent molecular investigations have identified a number of genetic alterations that
are associated with the development of pituitary adenomas, the exact pathogenesis
mechanism of these tumors remains largely unknown. In this study, we used a genome-wide
survey to detect specific genetic changes within the genome of pituitary adenomas. A series
of 10 growth hormone-secreting adenomas were analyzed for their genetic imbalances on
all 22 autosomes by comparative genomic hybridization (CGH). Chromosomal imbalances …
are associated with the development of pituitary adenomas, the exact pathogenesis
mechanism of these tumors remains largely unknown. In this study, we used a genome-wide
survey to detect specific genetic changes within the genome of pituitary adenomas. A series
of 10 growth hormone-secreting adenomas were analyzed for their genetic imbalances on
all 22 autosomes by comparative genomic hybridization (CGH). Chromosomal imbalances …