The efficacy of iso-and hyperosmotic fluids as volume expanders in fixed-volume and uncontrolled hemorrhage
MC Mazzoni, P Borgstrom, KE Arfors… - Annals of emergency …, 1990 - Elsevier
Rapid blood volume expansion is the goal in prehospital hemorrhage resuscitation. A
comparison was made for fixed volume and uncontrolled hemorrhage between three fluid
regimes: Ringer's lactate (RL), Macrodex®(MD), or a small volume of a hyperosmotic
solution (HSD, 7.5% NaCl/6% dextran 70) followed by RL. A mathematical model was
developed to simulate blood volume restoration for these given hemorrhage and
resuscitation situations. Model predictions for a fixed hemorrhage (35%) and reinfusion of …
comparison was made for fixed volume and uncontrolled hemorrhage between three fluid
regimes: Ringer's lactate (RL), Macrodex®(MD), or a small volume of a hyperosmotic
solution (HSD, 7.5% NaCl/6% dextran 70) followed by RL. A mathematical model was
developed to simulate blood volume restoration for these given hemorrhage and
resuscitation situations. Model predictions for a fixed hemorrhage (35%) and reinfusion of …