Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver …
AM Diehl, SQ Yang, M Yin, HZ Lin, S Nelson, G Bagby - Hepatology, 1995 - Elsevier
Injury-related cytokines, such as tumor necrosis factor-alpha (TNF), may preserve liver-
specific gene expression during the subsequent regenerative response by modulating the
activity of transcription factors, including CCAAT/enhancer binding proteins (C/EBPs), which
regulate differentiated gene expression in hepatocytes. To test this theory, rats were treated
with neutralizing antibody to TNF or nonimmune immunoglobulin before partial hepatectomy
(PH) and regenerative changes in the messenger RNAs (mRNAs), proteins, and DNA …
specific gene expression during the subsequent regenerative response by modulating the
activity of transcription factors, including CCAAT/enhancer binding proteins (C/EBPs), which
regulate differentiated gene expression in hepatocytes. To test this theory, rats were treated
with neutralizing antibody to TNF or nonimmune immunoglobulin before partial hepatectomy
(PH) and regenerative changes in the messenger RNAs (mRNAs), proteins, and DNA …