Antigen-selected T-cell receptor diversity and self-nonself homology
JL Casanova, JL Maryanski - Immunology today, 1993 - cell.com
JL Casanova, JL Maryanski
Immunology today, 1993•cell.comRecent studies mdtcate that the T-cell receptor (TCR) repertoire selected by certam
antigenic peptide-MHC combinations can be extremely &verse. This is in contrast to earher
studies reportmg T-cell responses which were limited in terms of TCR diversity. In this
v&wpoint, we suggest these variations in TCR &versity may be explained by taking into
account the homology between some antigens and self proteins to which T cells are tolerant.
The mouse T-cell response to the antigenic site 81-104 of the pigeon cytochrome cm the …
antigenic peptide-MHC combinations can be extremely &verse. This is in contrast to earher
studies reportmg T-cell responses which were limited in terms of TCR diversity. In this
v&wpoint, we suggest these variations in TCR &versity may be explained by taking into
account the homology between some antigens and self proteins to which T cells are tolerant.
The mouse T-cell response to the antigenic site 81-104 of the pigeon cytochrome cm the …
Recent studies mdtcate that the T-cell receptor (TCR) repertoire selected by certam antigenic peptide-MHC combinations can be extremely &verse. This is in contrast to earher studies reportmg T-cell responses which were limited in terms of TCR diversity. In this v&wpoint, we suggest these variations in TCR &versity may be explained by taking into account the homology between some antigens and self proteins to which T cells are tolerant.
The mouse T-cell response to the antigenic site 81-104 of the pigeon cytochrome cm the context of the class II major hlstocompanbdlty complex (MHC) molecules IE k was the first analysed in terms of T-cell receptor (TCR) diversity 1-7. The TCRs selected by this peptide-MHC complex were found to display very conserved structural features, both m terms of V., J., V~
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