Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Mechanisms responsible for 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced
dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether
neuronal death does occur. In vitro studies suggest that 1-methyl-4-phenylpyridinium ion
(MPP+), the active metabolite of MPTP, kills neurons by apoptosis. Herein, we investigated
whether MPTP induces DA neuronal death in vivo in mice and whether the mechanism is
that of apoptosis. C57/bl Mice received different doses of MPTP administered in four …
dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether
neuronal death does occur. In vitro studies suggest that 1-methyl-4-phenylpyridinium ion
(MPP+), the active metabolite of MPTP, kills neurons by apoptosis. Herein, we investigated
whether MPTP induces DA neuronal death in vivo in mice and whether the mechanism is
that of apoptosis. C57/bl Mice received different doses of MPTP administered in four …