Amyloid β-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of
short chain dehydrogenase/reductases whose distinctive properties include the capacity to
bind amyloid β-peptide and enzymatic activity toward a broad array of substrates including n-
isopropanol and β-estradiol. In view of the wide substrate specificity of ABAD and its high
activity on l-β-hydroxyacyl-CoA derivatives, we asked whether it might also catalyze the
oxidation of the ketone body d-3-hydroxybutyrate. This was indeed the case, and oxidation …