Platelet-derived growth factor (PDGF) was one of the first polypeptide growth factors
identified that signals through a cell surface tyrosine kinase receptor (PDGF-R) to stimulate
various cellular functions including growth, proliferation, and differentiation. Since then,
several related genes have been identified constituting a family of ligands (primarily PDGF A
and B) and their cognate receptors (PDGF-R α and β). To date, PDGF expression has been
shown in a number of different solid tumors, from glioblastomas to prostate carcinomas. In …