High-dose antithrombin III in severe sepsis: a randomized controlled trial
BL Warren, A Eid, P Singer, SS Pillay, P Carl, I Novak… - Jama, 2001 - jamanetwork.com
ContextActivation of the coagulation system and depletion of endogenous anticoagulants
are frequently found in patients with severe sepsis and septic shock. Diffuse microthrombus
formation may induce organ dysfunction and lead to excess mortality in septic shock.
Antithrombin III may provide protection from multiorgan failure and improve survival in
severely ill patients. ObjectiveTo determine if high-dose antithrombin III (administered within
6 hours of onset) would provide a survival advantage in patients with severe sepsis and …
are frequently found in patients with severe sepsis and septic shock. Diffuse microthrombus
formation may induce organ dysfunction and lead to excess mortality in septic shock.
Antithrombin III may provide protection from multiorgan failure and improve survival in
severely ill patients. ObjectiveTo determine if high-dose antithrombin III (administered within
6 hours of onset) would provide a survival advantage in patients with severe sepsis and …