[HTML][HTML] Allograft rejection in a new allospecific CD4+ TCR transgenic mouse
MH Sayegh, Z Wu, WW Hancock, PB Langmuir… - American Journal of …, 2003 - Elsevier
The application of TCR transgenic mice to transplantation immunology is hampered by the
limited lines available. Recently, we reported CD4+ T cell receptor (TCR) transgenic mice
specific for IA bm12 expressed on B6. CH-2 bm12 mice. Here, we characterized rejection of
skin and vascularized cardiac allografts in these mice, which we term ABM (for anti-bm12).
In vivo proliferative experiments reveal that all CD4 T cells in ABM mice react to bm12
antigens. Surprisingly, while ABM mice have accelerated (compared to B6 recipients) …
limited lines available. Recently, we reported CD4+ T cell receptor (TCR) transgenic mice
specific for IA bm12 expressed on B6. CH-2 bm12 mice. Here, we characterized rejection of
skin and vascularized cardiac allografts in these mice, which we term ABM (for anti-bm12).
In vivo proliferative experiments reveal that all CD4 T cells in ABM mice react to bm12
antigens. Surprisingly, while ABM mice have accelerated (compared to B6 recipients) …