Serum imbalance of cytokines in melanoma patients
S Moretti, A Chiarugi, F Semplici, A Salvi… - Melanoma …, 2001 - journals.lww.com
The cytokines interleukin (IL) 6 and IL10 appear to be involved in the progression of
melanoma because they are secreted by malignant cells and their serum levels are
associated with poor survival and with advanced stages of the disease. Antitumour immunity
is considered to be a T-cell response, mediated mainly by type 1 cytokines such as IL12 and
interferon-γ (IFNγ). We evaluated the serum levels of cytokines involved in the host response
against tumour (IL12, IFNγ) and/or the progression of melanoma (IL6, IL10) in 45 melanoma …
melanoma because they are secreted by malignant cells and their serum levels are
associated with poor survival and with advanced stages of the disease. Antitumour immunity
is considered to be a T-cell response, mediated mainly by type 1 cytokines such as IL12 and
interferon-γ (IFNγ). We evaluated the serum levels of cytokines involved in the host response
against tumour (IL12, IFNγ) and/or the progression of melanoma (IL6, IL10) in 45 melanoma …