[HTML][HTML] Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex
JP Medema, C Scaffidi, PH Krammer… - Journal of Biological …, 1998 - ASBMB
The Bcl-2 family member Bcl-x L has often been correlated with apoptosis resistance. We
have shown recently that in peripheral human T cells resistance to CD95-mediated
apoptosis is characterized by a lack of caspase-8 recruitment to the CD95 death-inducing
signaling complex (DISC) and by increased expression of Bcl-x L (Peter, ME, Kischkel, FC,
Scheuerpflug, CG, Medema, JP, Debatin, K.-M., and Krammer, PH (1997) Eur. J. Immunol.
27, 1207–1212). This raises the possibility that Bcl-x L directly prevents caspase-8 activation …
have shown recently that in peripheral human T cells resistance to CD95-mediated
apoptosis is characterized by a lack of caspase-8 recruitment to the CD95 death-inducing
signaling complex (DISC) and by increased expression of Bcl-x L (Peter, ME, Kischkel, FC,
Scheuerpflug, CG, Medema, JP, Debatin, K.-M., and Krammer, PH (1997) Eur. J. Immunol.
27, 1207–1212). This raises the possibility that Bcl-x L directly prevents caspase-8 activation …