[HTML][HTML] c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

RJ Clem, TT Sheu, BWM Richter, WW He… - Journal of Biological …, 2001 - ASBMB
Although human c-IAP1 and c-IAP2 have been reported to possess antiapoptotic activity
against a variety of stimuli in several mammalian cell types, we observed that full-length c-
IAP1 and c-IAP2 failed to protect cells from apoptosis induced by Bax overexpression, tumor
necrosis factor α treatment or Sindbis virus infection. However, deletion of the C-terminal
RING domains of c-IAP1 and c-IAP2 restored antiapoptotic activity, indicating that this region
negatively regulates the antiapoptotic function of the N-terminal BIR domain. This finding is …