[HTML][HTML] Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
Genetic analysis of apoptosis in the nematodeCaenorhabditis elegans has revealed the cell
death machine to be composed of three core interacting components. CED-4 (equivalent to
mammalian Apaf-1) is a nucleotide binding molecule that complexes with the zymogen form
of the death protease CED-3, leading to its autoactivation and cell death. CED-9 blocks
death by complexing with CED-4 and attenuating its ability to promote CED-3 activation. An
equivalent ternary complex was found to be present in mammalian cells involving Apaf-1 …
death machine to be composed of three core interacting components. CED-4 (equivalent to
mammalian Apaf-1) is a nucleotide binding molecule that complexes with the zymogen form
of the death protease CED-3, leading to its autoactivation and cell death. CED-9 blocks
death by complexing with CED-4 and attenuating its ability to promote CED-3 activation. An
equivalent ternary complex was found to be present in mammalian cells involving Apaf-1 …