[HTML][HTML] Protein GRAB of Streptococcus pyogenes regulates proteolysis at the bacterial surface by binding α2-macroglobulin
M Rasmussen, HP Muller, L Björck - Journal of Biological Chemistry, 1999 - ASBMB
In the molecular interplay between pathogenic microorganisms and their host, proteolytic
mechanisms are believed to play a crucial role. Here we find that the important human
pathogenStreptococcus pyogenes (group A Streptococcus) expresses a surface protein with
high affinity (K a= 2.0× 10 8 m− 1) for α 2-macroglobulin (α 2 M), the dominating proteinase
inhibitor of human plasma. The immunoglobulin-binding protein G of group C and G
streptococci also contains an α 2 M-binding domain and a gene encoding protein GRAB …
mechanisms are believed to play a crucial role. Here we find that the important human
pathogenStreptococcus pyogenes (group A Streptococcus) expresses a surface protein with
high affinity (K a= 2.0× 10 8 m− 1) for α 2-macroglobulin (α 2 M), the dominating proteinase
inhibitor of human plasma. The immunoglobulin-binding protein G of group C and G
streptococci also contains an α 2 M-binding domain and a gene encoding protein GRAB …