Biliary atresia and reovirus type 3 infection
R Morecki, JH Glaser, S Cho… - … England Journal of …, 1982 - Mass Medical Soc
R Morecki, JH Glaser, S Cho, WF Balistreri, MS Horwitz
New England Journal of Medicine, 1982•Mass Medical SocNEONATAL biliary atresia was originally thought to be a developmental malformation.
However, microscopical examination of bile ducts resected during portoenterostomy has
revealed inflammatory lesions suggesting an ongoing postnatal process such as infection. 1,
2 Viral isolation and serologic studies have usually been negative except for an occasional
case associated with cytomegalovirus or congenital rubella infection. 3 4 5 6 Our interest in
reovirus type 3 (reo-3) as a potential cause of biliary atresia was stimulated by the …
However, microscopical examination of bile ducts resected during portoenterostomy has
revealed inflammatory lesions suggesting an ongoing postnatal process such as infection. 1,
2 Viral isolation and serologic studies have usually been negative except for an occasional
case associated with cytomegalovirus or congenital rubella infection. 3 4 5 6 Our interest in
reovirus type 3 (reo-3) as a potential cause of biliary atresia was stimulated by the …
NEONATAL biliary atresia was originally thought to be a developmental malformation. However, microscopical examination of bile ducts resected during portoenterostomy has revealed inflammatory lesions suggesting an ongoing postnatal process such as infection.1 , 2 Viral isolation and serologic studies have usually been negative except for an occasional case associated with cytomegalovirus or congenital rubella infection.3 4 5 6
Our interest in reovirus type 3 (reo-3) as a potential cause of biliary atresia was stimulated by the observations of Stanley et al.7 They described chronic obstructive jaundice in mice, associated with choledochal obliteration that followed intraperitoneal injection of reo-3 into weanling animals.8 Although hepatic injury is . . .
The New England Journal Of Medicine