Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis
Infection and immunity, 2001•Am Soc Microbiol
The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-
D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive
pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7
days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80,
60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect
immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus …
D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive
pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7
days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80,
60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect
immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus …
Abstract
The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.
American Society for Microbiology