[HTML][HTML] Deletion mapping of N-terminal domains of surfactant protein A: the N-terminal segment is required for phospholipid aggregation and specific inhibition of …
FX McCormack, M Damodarasamy… - Journal of Biological …, 1999 - ASBMB
The objective of the current study was to examine the functional importance of the N-terminal
domains of surfactant protein A (SP-A) including the N-terminal segment from Asn 1 to Ala 7
(denoted domain 1), the N-terminal portion of the collagen domain from Gly 8 to Gly 44
(domain 2), and the C-terminal portion of the collagen-like domain from Gly 45 to Pro 80
(domain 3). Wild type recombinant SP-A (SP-A hyp; where hyp indicates hydroxyproline-
deficient) and truncated mutant (TM) SP-As containing deletions of domain (s) 1 (TM1), 2 …
domains of surfactant protein A (SP-A) including the N-terminal segment from Asn 1 to Ala 7
(denoted domain 1), the N-terminal portion of the collagen domain from Gly 8 to Gly 44
(domain 2), and the C-terminal portion of the collagen-like domain from Gly 45 to Pro 80
(domain 3). Wild type recombinant SP-A (SP-A hyp; where hyp indicates hydroxyproline-
deficient) and truncated mutant (TM) SP-As containing deletions of domain (s) 1 (TM1), 2 …